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St Vincent's Centre for Applied Medical Research

Bruce Brew

Professor Bruce Brew AM is Head of the Neurosciences Program at St Vincent's Centre for Applied Medical Research, and the Director of the Peter Duncan Neurosciences Research Unit at St Vincent's Centre for Applied Medical Research.

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Research Program: Peter Duncan Neurosciences Research Unit

Peter Duncan Neurosciences Research Unit

Bio

Professor Bruce Brew AM is Head of the Neurosciences Program at St Vincent's Centre for Applied Medical Research, and the Director of the Peter Duncan Neurosciences Research Unit at St Vincent's Centre for Applied Medical Research. Prof. Brew is an experienced neurologist with a particular interest in dementia, neurological complications of immune deficiencies, and infections of the nervous system. His research focuses on these areas of interest, and aims to understand and how to treat various brain diseases, stop damage processes and repair the brain. Prof. Brew is also involved in teaching and holds appointments as a Conjoint Professor at the University of New South Wales and Professor at the University of Notre Dame. He has served on the editorial boards of several prominent journals, been a member of several international advisory boards, published over 500 papers, authored four books, and has over 35,000 citations (H-index 98 by Google Scholar).
Bruce Brew

PublicationsSelected Publications from Bruce Brew

  • Ayton S, Barton D, Brew B, Brodtmann A, Clarnette R, Desmond P, Devos D, Ellis KA, Fazlollahi A, Fradette C, Goh AMY, Kalinowski P, Kyndt C, Lai R, Lim YY, Maruff P, O'Brien TJ, Rowe C, Salvado O, Schofield PW, Spino M, Tricta F, Wagen A, Williams R, Woodward M, Bush AI. Deferiprone in Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2025;82(1):11-18.
  • Cysique LA, Jakabek D, Bracken SG, Allen-Davidian Y, Heng B, Chow S, Dehhaghi M, Staats Pires A, Darley DR, Byrne A, Phetsouphanh C, Kelleher A, Dore GJ, Matthews GV, Guillemin GJ, Brew BJ. The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC. Ann Clin Transl Neurol. 2023;10(8):1338-1352.
  • Suzuki K, Zaunders J, Gates TM, Levert A, Butterly S, Liu Z, Ishida T, Palmer S, Rae CD, Jugé L, Cysique LA, Brew BJ. Elevation of cell-associated HIV-1 transcripts in CSF CD4+ T cells, despite effective antiretroviral therapy, is linked to brain injury. Proc Natl Acad Sci U S A. 2022;119(48):e2210584119.
  • Jakabek D, Rae CD, Brew BJ, Cysique LA. Brain aging and cardiovascular factors in HIV: a longitudinal volume and shape MRI study. AIDS. 2022;36(6):785-794.
  • Sundaram G, Lim CK, Brew BJ, Guillemin GJ. Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression. J Neuroinflammation. 2020;17(1):176.