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St Vincent's Centre for Applied Medical Research

Samuel Breit

Professor Breit heads the Inflammation and Cytokine Biology Research Program at St Vincent's Centre of Applied Medical Research as well as being a Clinical Immunologist and Immunopathologist at St Vincent's Hospital Sydney.

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Research Program: Inflammation and Cytokine Biology Research Program

Inflammation and Cytokine Biology Research Program

Bio

Professor Breit heads the Inflammation and Cytokine Biology Research Program at St Vincent's Centre of Applied Medical Research as well as being a Clinical Immunologist and Immunopathologist at St Vincent's Hospital Sydney. Prof. Breit is a Conjoint Professor of Medicine at UNSW, with over 180 peer reviewed publications, and is an inventor on many patents. His research has focused on two molecules, which his group first discovered and characterised over a decade ago: CLIC1 and MIC-1/GDF15 (now GDF15). Prof. Breit collaborates widely and maintains an active research program, involving postdoctoral scientists and PhD students, in his pursuit of translating laboratory discoveries into practical medical applications.
Samuel Breit

PublicationsSelected Publications from Samuel Breit

  • Tsai V. W. W., H. P. Zhang, R. Manandhar, P. Schofield, D. Christ, K. K. M. Lee-Ng, H. Lebhar, C. P. Marquis, Y. Husaini, D. A. Brown, and S. N. Breit. GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS. Int J Obes (Lond). 2019. 43:2370-2380. doi: 10.1038/s41366-019-0365-5. PMID 31152154
  • Vicky WW Tsai, David A Brown, Samuel N Breit. The GDF15-GFRAL pathway in health and metabolic disease. Annual Reviews of Physiology. 2021.83:127-151. doi: 10.1146/annurev-physiol-022020-045449. Epub 2020 Nov 23. PMID: 33228454
  • Breit, S. N., D. A. Brown, and V. W. W. Tsai. GDF15 analogs as obesity therapeutics. Cell Metab. 2023: 35:227-228. PMID: 36754014 DOI: 10.1016/j.cmet.2023.01.002
  • Breit SN, Manandhar R, Zhang HP, Lee-Ng M, Brown DA, Tsai VW. GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway. Cell Metab. 2023 Aug 8;35(8):1341-1355.e3. doi:10.1016/j.cmet.2023.06.009. Epub 2023 Jul 10. PMID: 37433299
  • Breit SN, Brown DA, Tsai VWW. GDF15 research from bench to bedside. Cancer Cell. 2024 42(11):1823-1824. doi: 10.1016/j.ccell.2024.10.002. PMID: 39454578.
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